At the beginning of the war, the He 115 was used for dropping parachute mines in British waters, normally aiming for narrow passages in close vicinity of heavily-trafficked ports on the English south coast. The River Thames was also a prime target. However, the aircraft had its finest moment when operating in the anti-shipping role against the Arctic convoys from bases in Northern Norway. Because these convoys initially lacked air cover, the low speed and comparatively light armament of the He 115 was not such a big problem as it had been over the heavily-defended English coastline. Later on, with the appearance of carriers and escort carriers, coupled with new Soviet heavy fighters like the Petlyakov Pe-3bis, the air superiority over the convoys was challenged, and as a result, the torpedo bomber losses were increasing.
Apart from its use as a minelayer and torpedo bomber, it was also used in the coastal reconnaissance role.